Trajectories of cortical thickness maturation in normal brain development--The importance of quality control procedures.

ABSTRACT: Several reports have described cortical thickness (CTh) developmental trajectories, with conflicting results. Some studies have reported inverted-U shape curves with peaks of CTh in late childhood to adolescence, while others suggested predominant monotonic decline after age 6. In this study, we reviewed CTh developmental trajectories in the NIH MRI Study of Normal Brain Development, and in a second step, evaluated the impact of post-processing quality control (QC) procedures on identified trajectories. The quality-controlled sample included 384 individual subjects with repeated scanning (1-3 per subject, total scans n=753) from 4.9 to 22.3years of age. The best-fit model (cubic, quadratic, or first-order linear) was identified at each vertex using mixed-effects models. The majority of bra

SUBMITTER: Ducharme S 

PROVIDER: S-EPMC4691414 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature