Macrophage autophagy limits acute toxic liver injury in mice through down regulation of interleukin-1β.

ABSTRACT:

Background & aims

Overactivation of the innate immune response underlies many forms of liver injury including that caused by hepatotoxins. Recent studies have demonstrated that macrophage autophagy regulates innate immunity and resultant tissue inflammation. Although hepatocyte autophagy has been shown to modulate hepatic injury, little is known about the role of autophagy in hepatic macrophages during the inflammatory response to acute toxic liver injury. Our aim therefore was to determine whether macrophage autophagy functions to down regulate hepatic inflammation.

Methods

Mice with a LysM-CRE-mediated macrophage knockout of the autophagy gene ATG5 were examined for their response to toxin-induced liver injury from D-galactosamine/lipopolysaccharide (GalN/LPS).

Results<

SUBMITTER: Ilyas G 

PROVIDER: S-EPMC4691423 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature