Hepatocyte tissue factor contributes to the hypercoagulable state in a mouse model of chronic liver injury.

ABSTRACT:

Background & aims

Patients with chronic liver disease and cirrhosis have a dysregulated coagulation system and are prone to thrombosis. The basis for this hypercoagulable state is not completely understood. Tissue factor (TF) is the primary initiator of coagulation in vivo. Patients with cirrhosis have increased TF activity in white blood cells and circulating microparticles. The aim of our study was to determine the contribution of TF to the hypercoagulable state in a mouse model of chronic liver injury.

Methods

We measured levels of TF activity in the liver, white blood cells and circulating microparticles, and a marker of activation of coagulation (thrombin-antithrombin complexes (TATc)) in the plasma of mice subjected to bile duct ligation for 12days. We used wild-type m

SUBMITTER: Rautou PE 

PROVIDER: S-EPMC4691429 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature