Ontology highlight
ABSTRACT:
SUBMITTER: Rupaimoole R
PROVIDER: S-EPMC4691557 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151210 11
Long noncoding RNAs (lncRNAs) significantly influence the development and regulation of genome expression in cells. Here, we demonstrate the role of lncRNA ceruloplasmin (NRCP) in cancer metabolism and elucidate functional effects leading to increased tumor progression. NRCP was highly upregulated in ovarian tumors, and knockdown of NRCP resulted in significantly increased apoptosis, decreased cell proliferation, and decreased glycolysis compared with control cancer cells. In an orthotopic mouse ...[more]