Genetic polymorphisms that affect selenium status and response to selenium supplementation in United Kingdom pregnant women.

ABSTRACT:

Background

Low selenium status in pregnancy has been associated with a number of adverse conditions. In nonpregnant populations, the selenium status or response to supplementation has been associated with polymorphisms in dimethylglycine dehydrogenase (DMGDH), selenoprotein P (SEPP1) and the glutathione peroxidases [cytosolic glutathione peroxidase (GPx1) and phospholipid glutathione peroxidase (GPx4)].

Objective

We hypothesized that, in pregnant women, these candidate polymorphisms would be associated with selenium status in early pregnancy, its longitudinal change, and the interindividual response to selenium supplementation at 60 μg/d.

Design

With the use of stored samples and data from the United Kingdom Selenium in Pregnancy Intervention (SPRINT) study in 227 pre

SUBMITTER: Mao J 

PROVIDER: S-EPMC4691667 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature