Is there a causal role for homocysteine concentration in blood pressure? A Mendelian randomization study.

ABSTRACT:

Background

An understanding of whether homocysteine is a cause or a marker of increased blood pressure is relevant because blood homocysteine can be effectively lowered by safe and inexpensive interventions (e.g., vitamin B-6, B-9, and B-12 supplementation).

Objective

The aim was to assess the causal influence of homocysteine on systolic and diastolic blood pressure (SBP and DBP, respectively) in adults with the use of Mendelian randomization (MR).

Design

Data from the 1982 Pelotas Birth Cohort (Brazil) were used. A total of 4297 subjects were evaluated in 2004-2005 (mean age: 22.8 y). The association of homocysteine concentration with SBP and DBP was assessed by conventional ordinary least-squares (OLS) linear regression and 2-stage least-squares (2SLS) regression (M

SUBMITTER: Borges MC 

PROVIDER: S-EPMC4691668 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature