Dietary nitrate improves vascular function in patients with hypercholesterolemia: a randomized, double-blind, placebo-controlled study.

ABSTRACT:

Background

The beneficial cardiovascular effects of vegetables may be underpinned by their high inorganic nitrate content.

Objective

We sought to examine the effects of a 6-wk once-daily intake of dietary nitrate (nitrate-rich beetroot juice) compared with placebo intake (nitrate-depleted beetroot juice) on vascular and platelet function in untreated hypercholesterolemics.

Design

A total of 69 subjects were recruited in this randomized, double-blind, placebo-controlled parallel study. The primary endpoint was the change in vascular function determined with the use of ultrasound flow-mediated dilatation (FMD).

Results

Baseline characteristics were similar between the groups, with primary outcome data available for 67 patients. Dietary nitrate resulted in an abso

SUBMITTER: Velmurugan S 

PROVIDER: S-EPMC4691670 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature