IV thrombolysis in very severe and severe ischemic stroke: Results from the SITS-ISTR Registry.

ABSTRACT:

Objective

To study the safety of off-label IV thrombolysis in patients with very severe stroke (NIH Stroke Scale [NIHSS] scores >25) compared with severe stroke (NIHSS scores 15-25), where treatment is within European regulations.

Methods

Data were analyzed from 57,247 patients with acute ischemic stroke receiving IV tissue plasminogen activator in 793 hospitals participating in the Safe Implementation of Thrombolysis in Stroke (SITS) International Stroke Thrombolysis Registry (2002-2013). Eight hundred sixty-eight patients (1.5%) had NIHSS scores >25 and 19,995 (34.9%) had NIHSS scores 15-25. Outcome measures were parenchymal hemorrhage, symptomatic intracerebral hemorrhage, mortality, and functional outcome.

Results

Parenchymal hemorrhage occurred in 10.7% vs 11.0%

SUBMITTER: Mazya MV 

PROVIDER: S-EPMC4691682 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature