Patient-Reported Impact of Symptoms in Myotonic Dystrophy Type 2 (PRISM-2).

ABSTRACT:

Objective

To determine the frequency and relative importance of the most life-affecting symptoms in myotonic dystrophy type 2 (DM2) and to identify the factors that have the strongest association with these symptoms.

Methods

We conducted a cross-sectional study of adult patients with DM2 from a National Registry of DM2 Patients to assess the prevalence and relative importance of 310 symptoms and 21 symptomatic themes. Participant responses were compared by age categories, sex, educational attainment, employment status, and duration of symptoms.

Results

The symptomatic themes with the highest prevalence in DM2 were the inability to do activities (94.4%), limitations with mobility or walking (89.2%), hip, thigh, or knee weakness (89.2%), fatigue (89.2%), and myotonia (8

SUBMITTER: Heatwole C 

PROVIDER: S-EPMC4691689 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature