Nitrate/Nitrite as Critical Mediators to Limit Oxidative Injury and Inflammation.

ABSTRACT:

Significance

Nitric oxide (NO) is a critical signaling molecule marked by complex chemistry and varied biological responses depending on the context of the redox environment. In the setting of inflammation, NO can not only contribute to tissue injury and be causative of oxidative damage but can also signal as an adaptive molecule to limit inflammatory signaling in multiple cell types and tissues.

Recent advances

An advance in our understanding of NO biology was the recognition of the nitrate-nitrite-NO axis, whereby nitrate (predominantly from dietary sources) could be converted to nitrite and nitrite could be reduced to NO.

Critical issues

Intriguingly, the recognition of multiple enzymes that serve as nitrite reductases in the setting of hypoxia or ischemia establis

SUBMITTER: Waltz P 

PROVIDER: S-EPMC4692126 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature