Threat-related amygdala functional connectivity is associated with 5-HTTLPR genotype and neuroticism.

ABSTRACT: Communication between the amygdala and other brain regions critically regulates sensitivity to threat, which has been associated with risk for mood and affective disorders. The extent to which these neural pathways are genetically determined or correlate with risk-related personality measures is not fully understood. Using functional magnetic resonance imaging, we evaluated independent and interactive effects of the 5-HTTLPR genotype and neuroticism on amygdala functional connectivity during an emotional faces paradigm in 76 healthy individuals. Functional connectivity between left amygdala and medial prefrontal cortex (mPFC) and between both amygdalae and a cluster including posterior cingulate cortex, precuneus and visual cortex was significantly increased in 5-HTTLPR S' allele carriers

SUBMITTER: Madsen MK 

PROVIDER: S-EPMC4692322 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature