RNA-Binding Proteins in Trichomonas vaginalis: Atypical Multifunctional Proteins.

ABSTRACT: Iron homeostasis is highly regulated in vertebrates through a regulatory system mediated by RNA-protein interactions between the iron regulatory proteins (IRPs) that interact with an iron responsive element (IRE) located in certain mRNAs, dubbed the IRE-IRP regulatory system. Trichomonas vaginalis, the causal agent of trichomoniasis, presents high iron dependency to regulate its growth, metabolism, and virulence properties. Although T. vaginalis lacks IRPs or proteins with aconitase activity, possesses gene expression mechanisms of iron regulation at the transcriptional and posttranscriptional levels. However, only one gene with iron regulation at the transcriptional level has been described. Recently, our research group described an iron posttranscriptional regulatory mechanism in the T.

SUBMITTER: Figueroa-Angulo EE 

PROVIDER: S-EPMC4693282 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature