Characterization of a set of tumor suppressor microRNAs in T cell acute lymphoblastic leukemia.

ABSTRACT: The posttranscriptional control of gene expression by microRNAs (miRNAs) is highly redundant, and compensatory effects limit the consequences of the inactivation of individual miRNAs. This implies that only a few miRNAs can function as effective tumor suppressors. It is also the basis of our strategy to define functionally relevant miRNA target genes that are not under redundant control by other miRNAs. We identified a functionally interconnected group of miRNAs that exhibited a reduced abundance in leukemia cells from patients with T cell acute lymphoblastic leukemia (T-ALL). To pinpoint relevant target genes, we applied a machine learning approach to eliminate genes that were subject to redundant miRNA-mediated control and to identify those genes that were exclusively targeted by tumor-s

SUBMITTER: Sanghvi VR 

PROVIDER: S-EPMC4693296 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature