Cognitive endophenotypes inform genome-wide expression profiling in schizophrenia.

ABSTRACT:

Objective

We performed a whole-genome expression study to clarify the nature of the biological processes mediating between inherited genetic variations and cognitive dysfunction in schizophrenia.

Method

Gene expression was assayed from peripheral blood mononuclear cells using Illumina Human WG6 v3.0 chips in twins discordant for schizophrenia or bipolar disorder and control twins. After quality control, expression levels of 18,559 genes were screened for association with the California Verbal Learning Test (CVLT) performance, and any memory-related probes were then evaluated for variation by diagnostic status in the discovery sample (N = 190), and in an independent replication sample (N = 73). Heritability of gene expression using the twin design was also assessed.

Result

SUBMITTER: Zheutlin AB 

PROVIDER: S-EPMC4693618 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature