Network dysfunction in α-synuclein transgenic mice and human Lewy body dementia.

ABSTRACT:

Objective

Dementia with Lewy bodies (DLB) is associated with the accumulation of wild-type human α-synuclein (SYN) in neurons and with prominent slowing of brain oscillations on electroencephalography (EEG). However, it remains uncertain whether the EEG abnormalities are actually caused by SYN.

Methods

To determine whether SYN can cause neural network abnormalities, we performed EEG recordings and analyzed the expression of neuronal activity-dependent gene products in SYN transgenic mice. We also carried out comparative analyses in humans with DLB.

Results

We demonstrate that neuronal expression of SYN in transgenic mice causes a left shift in spectral power that closely resembles the EEG slowing observed in DLB patients. Surprisingly, SYN mice also had seizures and s

SUBMITTER: Morris M 

PROVIDER: S-EPMC4693622 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature