Renin-Angiotensin System Blockade Associated with Statin Improves Endothelial Function in Diabetics.

ABSTRACT:

Background

Studies suggest that statins have pleiotropic effects, such as reduction in blood pressure, and improvement in endothelial function and vascular stiffness.

Objective

To analyze if prior statin use influences the effect of renin-angiotensin-aldosterone system inhibitors on blood pressure, endothelial function, and vascular stiffness.

Methods

Patients with diabetes and hypertension with office systolic blood pressure ≥ 130 mmHg and/or diastolic blood pressure ≥ 80 mmHg had their antihypertensive medications replaced by amlodipine during 6 weeks. They were then randomized to either benazepril or losartan for 12 additional weeks while continuing on amlodipine. Blood pressure (assessed with ambulatory blood pressure monitoring), endothelial function (brachial ar

SUBMITTER: Gismondi RA 

PROVIDER: S-EPMC4693664 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature