RNA Helicase Important for Listeria monocytogenes Hemolytic Activity and Virulence Factor Expression.

ABSTRACT: RNA helicases have been shown to be important for the function of RNA molecules at several levels, although their putative involvement in microbial pathogenesis has remained elusive. We have previously shown that Listeria monocytogenes DExD-box RNA helicases are important for bacterial growth, motility, ribosomal maturation, and rRNA processing. We assessed the importance of the RNA helicase Lmo0866 (here named CshA) for expression of virulence traits. We observed a reduction in hemolytic activity in a strain lacking CshA compared to the wild type. This phenomenon was less evident in strains lacking other RNA helicases. The reduced hemolysis was accompanied by lower expression of major listerial virulence factors in the ΔcshA strain, mainly listeriolysin O, but also to some degree the acti

SUBMITTER: Netterling S 

PROVIDER: S-EPMC4693997 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature