Screening of a kinase library reveals novel pro-senescence kinases and their common NF-κB-dependent transcriptional program.

ABSTRACT: Cellular senescence results in proliferation arrest and acquisition of hallmarks such as the Senescence-Associated Secretory Phenotype (SASP). Senescence is involved in regulating numerous physio-pathological responses, including embryonic development, cancer, and several aging-related diseases. Only a few kinases, centered on the RAS signaling pathway, have been identified as inducing premature senescence. About possible other senescence-regulating kinases and signaling pathways, practically little is known. By screening a library of activated kinases, we identified 33 kinases whose constitutive expression decreases cell proliferation and induces expression of senescence markers; p16 and SASP components. Focusing on some kinases showing the strongest pro-senescence effects, we observed th

SUBMITTER: Ferrand M 

PROVIDER: S-EPMC4694068 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature