HLA-DRB1*14 is a protective allele for multiple sclerosis in an admixed Colombian population.

ABSTRACT:

Objective

The aim of this study was to determine ancestry informative markers, mitochondrial DNA haplogroups, and the association between HLA-DRB1 alleles and multiple sclerosis (MS) in a group of patients from Bogotá, Colombia.

Methods

In this case-control study, genomic DNA was isolated and purified from blood samples. HLA-DRB1 allele genotyping was done using PCR. Mitochondrial hypervariable region 1 was amplified and haplogroups were determined using HaploGrep software. Genomic ancestry was estimated by genotyping a panel of ancestry informative markers. To test the association of HLA polymorphisms and MS, we ran separate multivariate logistic regression models. Bonferroni correction was used to account for multiple regression tests.

Results

A total of 100 patient

SUBMITTER: Toro J 

PROVIDER: S-EPMC4694072 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature