(1)H-NMR analysis provides a metabolomic profile of patients with multiple sclerosis.

ABSTRACT:

Objective

To investigate the metabolomic profiles of patients with multiple sclerosis (MS) and to define the metabolic pathways potentially related to MS pathogenesis.

Methods

Plasma samples from 73 patients with MS (therapy-free for at least 90 days) and 88 healthy controls (HC) were analyzed by (1)H-NMR spectroscopy. Data analysis was conducted with principal components analysis followed by a supervised analysis (orthogonal partial least squares discriminant analysis [OPLS-DA]). The metabolites were identified and quantified using Chenomx software, and the receiver operating characteristic (ROC) curves were calculated.

Results

The model obtained with the OPLS-DA identified predictive metabolic differences between the patients with MS and HC (R2X = 0.615, R2Y = 0.619

SUBMITTER: Cocco E 

PROVIDER: S-EPMC4694073 | biostudies-literature | 2016 Feb

REPOSITORIES: biostudies-literature