Genetics of murine craniofacial morphology: diallel analysis of the eight founders of the Collaborative Cross.

ABSTRACT: Using eight inbred founder strains of the mouse Collaborative Cross (CC) project and their reciprocal F1 hybrids, we quantified variation in craniofacial morphology across mouse strains, explored genetic contributions to craniofacial variation that distinguish the founder strains, and tested whether specific or summary measures of craniofacial shape display stronger additive genetic contributions. This study thus provides critical information about phenotypic diversity among CC founder strains and about the genetic contributions to this phenotypic diversity, which is relevant to understanding the basis of variation in standard laboratory strains and natural populations. Craniofacial shape was quantified as a series of size-adjusted linear dimensions (RDs) and by principal components (PC) a

SUBMITTER: Percival CJ 

PROVIDER: S-EPMC4694168 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature