Prognostic significance of MiR-34a in solid tumors: a systemic review and meta-analysis with 4030 patients.

ABSTRACT:

Purpose

The aim of the present meta-analysis and systematic review was to explore the association between the expression of miR-34a and prognosis in solid tumor.

Methods

PubMed, Google Scholar, Web of Science and NCBI databases were used to search studies to evaluate the effect of miR-34a expression on clinical outcomes, including overall survival (OS), recurrence-free survival (RFS), disease-free survival (DFS), progression-free survival (PFS) and event-free survival (EFS) in solid tumor. The pooled random effect models were performed to calculate pooled hazard ratio (HR), 95% confidence interval (CI) to assess the association.

Results

Twenty-three eligible studies with 4030 patients were included in this meta-analysis. It was confirmed that increased expression of m

SUBMITTER: Ren F 

PROVIDER: S-EPMC4694229 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature