Peroxisome proliferator-activated receptor gamma rs1801282 C>G polymorphism is associated with polycystic ovary syndrome susceptibility: a meta-analysis involving 7,069 subjects.

ABSTRACT: In the peroxisome proliferator-activated receptor gamma (PPARG) gene, a polymorphism (rs1801282 C>G), has been shown to change an amino acid residue and then results in alternation of PPARG function. A number of studies have explored the relationship between PPARG rs1801282 C>G variants and polycystic ovary syndrome (PCOS) risk, but yielding inconsistent findings, especially in Asian population. This study aimed to assess the role of PPARG rs1801282 C>G polymorphism in susceptibility to PCOS. Databases of Pubmed, Embase and China National Knowledge Internet (CNKI) were searched until August 2, 2015. The association of PPARG 1801282 C>G polymorphism with PCOS risk was evaluated by crude odds ratios (ORs) with their 95% confidence intervals (CIs). Finally, there were twenty-three studies inv

SUBMITTER: Zhang S 

PROVIDER: S-EPMC4694232 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature