Association between polymorphism of the norepinephrine transporter gene rs2242446 and rs5669 loci and depression disorders.

ABSTRACT:

Objective

To explore the association between polymorphism of the norepinephrine transporter (NET) gene rs2242446 and rs5669 loci and depression in Chinese Han population.

Methods

A case-control study was carried out, the gene types and allele distributions of NFT gene rs2242446 and rs5569 loci in 302 depression patients and 302 healthy controls were detected by Taqman SNP genotyping technology.

Results

The gene types and allele frequency distributions of NFT gene rs2242446 and rs5569 loci had significant differences between case group and control group (rs2242446, x(2)=26.045, P<0.05, x(2)=8.827, P<0.05, rs5569, x(2)=42.47, P<0.05, x(2)=20.9, P<0.05). The CC genotype of NET gene rs2242446 locus and rs5569 loci was a protective factor of depression compared with the CT

SUBMITTER: Pan Y 

PROVIDER: S-EPMC4694404 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature