Role of abnormal anterior pituitary hormones-growth hormone and prolactin in active systemic lupus erythematosus.

ABSTRACT:

Background

The role of anterior pituitary hormones in systemic lupus erythematosus (SLE) remains controversial.

Aims and objectives

We determined the expression levels of human growth hormone (GH), prolactin (PRL), and their receptors in subjects presenting with SLE, and modulation of disease severity.

Materials and methods

Forty-seven subjects and ten healthy controls were assessed for possible association between SLE disease activity and levels of serum PRL, GH and thyrotropin-releasing hormone (TRH). In peripheral blood mononuclear cells (PBMC), specific binding and mRNA expression of receptors for GH (GHR), and PRL (PRLR) were determined by receptor-ligand binding assay (RLBA) and RT-PCR. PBMC of recruited subjects were treated with hPRL and rhGH to assess IgG pro

SUBMITTER: Zhu X 

PROVIDER: S-EPMC4694458 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature