Combining Evolutionary Information and an Iterative Sampling Strategy for Accurate Protein Structure Prediction.

ABSTRACT: Recent work has shown that the accuracy of ab initio structure prediction can be significantly improved by integrating evolutionary information in form of intra-protein residue-residue contacts. Following this seminal result, much effort is put into the improvement of contact predictions. However, there is also a substantial need to develop structure prediction protocols tailored to the type of restraints gained by contact predictions. Here, we present a structure prediction protocol that combines evolutionary information with the resolution-adapted structural recombination approach of Rosetta, called RASREC. Compared to the classic Rosetta ab initio protocol, RASREC achieves improved sampling, better convergence and higher robustness against incorrect distance restraints, making it the id

SUBMITTER: Braun T 

PROVIDER: S-EPMC4694711 | biostudies-literature | 2015 Dec

REPOSITORIES: biostudies-literature