MiRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin.

ABSTRACT: Maspin suppresses tumor progression by promoting cell adhesion and apoptosis and by inhibiting cell motility. However, its role in tumorigenesis of hepatocellular carcinoma (HCC) remains unclear. The gene regulation of maspin and its relationship with HCC patient prognosis were investigated in this study. Maspin expression was specifically reduced in HBV-associated patients and correlated with their poor prognosis. Maspin downregulation in HCC cells was induced by HBx to promote their motility and resistance to anoikis and chemotherapy. HBx-dependent induction of microRNA-7, -107, and -21 was further demonstrated to directly target maspin mRNA, leading to its protein downregulation. Higher expressions of these microRNAs also correlated with maspin downregulation in HBV-associated patients,

SUBMITTER: Chen WS 

PROVIDER: S-EPMC4694878 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature