Host genotype and tumor phenotype of chemokine decoy receptors integrally affect breast cancer relapse.

ABSTRACT: PURPOSE:Chemokines may play vital roles in breast cancer progression and metastasis. The primary members of chemokine decoy receptors (CDR), DARC and D6, are expressed in breast tumors and lymphatic/hematogenous vessels. CDRs sequestrate the pro-malignant chemokines. We hypothesized that breast cancer patients carrying different levels of CDR expression in tumor and/or in host might have differing clinical outcomes. METHODS:This prospective observational study measured both expression and germline genotype of DARC and D6 in 463 primary breast cancer patients enrolled between 2004 and 2006. The endpoint was breast cancer relapse-free survival (RFS). RESULTS:There was a significant association between the co-expression of CDR (immunohistochemical expression of both DARC and D6) with RFS (haz

SUBMITTER: Yu KD 

PROVIDER: S-EPMC4694919 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature