A network meta-analysis of the efficacy and side effects of UDCA-based therapies for primary sclerosing cholangitis.

ABSTRACT:

Objectives

Therapies for treatment of patients with primary sclerosing cholangitis (PSC) include administration of ursodeoxycholic acid (UDCA) alone, or combination with metronidazole (MTZ) or mycophenolate mofetil (MMF), respectively. However, the optimum regimen still remains inconclusive. We aimed to compare interventions in terms of patient mortality or liver transplantation (MOLT), progression of liver histological stage (POLHS), serum bilirubin, alkaline phosphatase (ALP) levels and adverse events (AE).

Methods

We searched PubMed, Embase and the Cochrane Library for randomized controlled trials until 31, Jan 2015. We estimated hazard ratios (HRs), odds ratios (ORs) and mean difference (MD) between treatments on clinical outcomes. Sensitivity analyses based on the dose

SUBMITTER: Zhu GQ 

PROVIDER: S-EPMC4694950 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature