Association of CELF2 polymorphism and the prognosis of nasopharyngeal carcinoma in southern Chinese population.

ABSTRACT: Nasopharyngeal carcinoma (NPC) is a malignancy with high metastatic potential and loco-regional recurrence. The overall survival of NPC has been limited from further improvement partly due to the lack of effective biomarker for accurate prognosis prediction and precise treatments. Here, in light of the implication of CELF gene family in cancer prognosis, we selected 112 tagging single nucleotide polymorphisms (SNPs) located in six members of the family and tested their associations with the clinical outcomes in a discovery cohort of 717 NPC patients. Survival analyses under multivariate cox proportional hazards model and Kaplan-Meier curve revealed five promising SNPs, which were further validated in another independent sample of 1,520 cases. Combined analysis revealed that SNP rs3740194 i

SUBMITTER: Guo YM 

PROVIDER: S-EPMC4694981 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature