Ontology highlight
ABSTRACT:
SUBMITTER: Jiang SS
PROVIDER: S-EPMC4694988 | biostudies-literature | 2015 Sep
REPOSITORIES: biostudies-literature
Oncotarget 20150901 29
Familial adenomatous polyposis (FAP) is an autosomal dominant disease manifesting as colorectal cancer in middle-aged patients. Mutations of the adenomatous polyposis coli (APC) gene contribute to both FAP and sporadic or familial colorectal carcinogenesis. Here we describe the identification of the causative APC gene defects associated with FAP in a Chinese pedigree. All patients with FAP were diagnosed by their combination of clinical features, family history, colonoscopy, and pathology examin ...[more]