Antitumor activity of the novel multi-kinase inhibitor EC-70124 in triple negative breast cancer.

ABSTRACT: Disseminated triple negative breast cancer (TNBC) is an incurable disease with limited therapeutic options beyond chemotherapy. Therefore, identification of druggable vulnerabilities is an important aim. Protein kinases play a central role in cancer and particularly in TNBC. They are involved in many oncogenic functions including migration, proliferation, genetic stability or maintenance of stem-cell like properties. In this article we describe a novel multi-kinase inhibitor with antitumor activity in this cancer subtype. EC-70124 is a hybrid indolocarbazole analog obtained by combinatorial biosynthesis of Rebeccamycin and Staurosporine genes that showed antiproliferative effect and in vivo antitumoral activity. Biochemical experiments demonstrated the inhibition of the PI3K/mTOR and JAK/S

SUBMITTER: Cuenca-Lopez MD 

PROVIDER: S-EPMC4695035 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature