Critical role of Wnt/β-catenin signaling in driving epithelial ovarian cancer platinum resistance.

ABSTRACT: Resistance to platinum-based chemotherapy is the major barrier to treating epithelial ovarian cancer. To improve patient outcomes, it is critical to identify the underlying mechanisms that promote platinum resistance. Emerging evidence supports the concept that platinum-based therapies are able to eliminate the bulk of differentiated cancer cells, but are unable to eliminate cancer initiating cells (CIC). To date, the relevant pathways that regulate ovarian CICs remain elusive. Several correlative studies have shown that Wnt/β-catenin pathway activation is associated with poor outcomes in patients with high-grade serous ovarian cancer (HGSOC). However, the functional relevance of these findings remain to be delineated. We have uncovered that Wnt/β-catenin pathway activation is a critical d

SUBMITTER: Nagaraj AB 

PROVIDER: S-EPMC4695147 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature