Optimal drug regimens for primary biliary cirrhosis: a systematic review and network meta-analysis.

ABSTRACT:

Objective

Most comprehensive treatments for PBC include UDCA, combination of methotrexate (MTX), corticosteroids (COT), colchicine (COC) or bezafibrate (BEF), cyclosporin A (CYP), D-penicillamine (DPM), methotrexate (MTX), or azathioprine (AZP). Since the optimum treatment regimen remains inconclusive, we aimed to compare these therapies in terms of patient mortality or liver transplantation (MOLT) and adverse event (AE).

Methods

We searched PubMed, Embase, Scopus and the Cochrane Library for randomized controlled trials until August 2014. We estimated HRs for MOLT and ORs for AE. The sensitivity analysis based on dose of UDCA was also performed.

Results

The search identified 49 studies involving 12 different treatment regimens and 4182 patients. Although no statistic

SUBMITTER: Zhu GQ 

PROVIDER: S-EPMC4695204 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature