Protocol Deviations before and after Treatment with Intravenous Tissue Plasminogen Activator in Community Hospitals.

ABSTRACT:

Background

Protocol deviations before and after tissue plasminogen activator (tPA) treatment for ischemic stroke are common. It is unclear if patient or hospital factors predict protocol deviations. We examined predictors of protocol deviations and the effects of protocol violations on symptomatic intracerebral hemorrhage (sICH).

Methods

We used data from the Increasing Stroke Treatment through Interventional Behavior Change Tactics trial, a cluster-randomized, controlled trial evaluating the efficacy of a barrier assessment and educational intervention to increase appropriate tPA use in 24 Michigan community hospitals, to review tPA treatments between 2007 and 2010. Protocol violations were defined as deviations from the standard tPA protocol, both before and after treatmen

SUBMITTER: Adelman EE 

PROVIDER: S-EPMC4695218 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature