African Ancestry Is Associated with Higher Intraocular Pressure in Latinos.

ABSTRACT:

Purpose

Intraocular pressure (IOP) is a major risk factor, as well as the only modifiable risk factor, for glaucoma. Racial differences have been observed in IOP measurements with individuals of African descent experiencing the highest IOP when compared with other ethnic groups. The purpose of this study was to examine the relationship between genetic ancestry and IOP in Latinos.

Design

Population-based genetic association study.

Participants

A total of 3541 participants recruited from the Los Angeles Latino Eye Study.

Methods

Study participants were genotyped using the Illumina OmniExpress BeadChip (∼730K markers). We used STRUCTURE to estimate individual genetic ancestry. Simple and multiple linear regression, as well as quantile regression, analyses were per

SUBMITTER: Nannini D 

PROVIDER: S-EPMC4695255 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature