Depression and clinical progression in spinocerebellar ataxias.

ABSTRACT:

Background

Depression is a common comorbidity in spinocerebellar ataxias (SCAs) but its association with ataxia progression is not well understood.

Objectives

To study the prevalence and influence of depressive symptoms in SCAs.

Methods

We studied 300 participants with SCA 1, 2, 3 and 6 from the Clinical Research Consortium for Spinocerebellar Ataxias (CRC-SCA) and repeatedly measured depressive symptoms by the 9-item Patient Health Questionnaire (PHQ-9) along with other clinical features including ataxia, functional status, and quality of life every 6 months for 2 years. We employed regression models to study the effects of depressive symptoms on clinical progression indexed by Scale for Assessment and Rating of Ataxia (SARA), Unified Huntington's Disease Rating Scal

SUBMITTER: Lo RY 

PROVIDER: S-EPMC4695274 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature