Comparative Effectiveness of First-Line Medications for Primary Open-Angle Glaucoma: A Systematic Review and Network Meta-analysis.

ABSTRACT:

Topic

Primary open-angle glaucoma (POAG) is a highly prevalent condition worldwide and the most common cause of irreversible sight loss. The objective is to assess the comparative effectiveness of first-line medical treatments in patients with POAG or ocular hypertension through a systematic review and network meta-analysis, and to provide relative rankings of these treatments.

Clinical relevance

Treatment for POAG currently relies completely on lowering the intraocular pressure (IOP). Although topical drops, lasers, and surgeries can be considered in the initial treatment of glaucoma, most patients elect to start treatment with eye drops.

Methods

We included randomized controlled trials (RCTs) that compared a single active topical medication with no treatment/placebo

SUBMITTER: Li T 

PROVIDER: S-EPMC4695285 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature