GFR Estimation Using β-Trace Protein and β2-Microglobulin in CKD.

ABSTRACT:

Background

β-Trace protein (BTP) and β2-microglobulin (B2M) are novel glomerular filtration markers that have stronger associations with adverse outcomes than creatinine. Comparisons of BTP and B2M to creatinine and cystatin C are limited by the absence of rigorously developed glomerular filtration rate (GFR) estimating equations for the novel markers.

Study design

Study of diagnostic test accuracy.

Setting & participants

Pooled database of 3 populations with chronic kidney disease (CKD) with mean measured GFR of 48 mL/min/1.73 m2 (N=3,551; MDRD [Modification of Diet in Renal Disease] Study, AASK [African American Study of Kidney Disease and Hypertension], and CRIC [Chronic Renal Insufficiency Cohort] Study).

Index tests

GFR estimated using creatinine, cystatin

SUBMITTER: Inker LA 

PROVIDER: S-EPMC4695294 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature