Porous, Dexamethasone-loaded polyurethane coatings extend performance window of implantable glucose sensors in vivo.

ABSTRACT: Continuous glucose sensors offer the promise of tight glycemic control for insulin dependent diabetics; however, utilization of such systems has been hindered by issues of tissue compatibility. Here we report on the in vivo performance of implanted glucose sensors coated with Dexamethasone-loaded (Dex-loaded) porous coatings employed to mediate the tissue-sensor interface. Two animal studies were conducted to (1) characterize the tissue modifying effects of the porous Dex-loaded coatings deployed on sensor surrogate implants and (2) investigate the effects of the same coatings on the in vivo performance of Medtronic MiniMed SOF-SENSOR™ glucose sensors. The tissue response to implants was evaluated by quantifying macrophage infiltration, blood vessel formation, and collagen density around i

SUBMITTER: Vallejo-Heligon SG 

PROVIDER: S-EPMC4695308 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature