Ontology highlight
ABSTRACT:
SUBMITTER: Del Pozo Martin Y
PROVIDER: S-EPMC4695340 | biostudies-literature | 2015 Dec
REPOSITORIES: biostudies-literature
Cell reports 20151206 11
During metastatic colonization, tumor cells must establish a favorable microenvironment or niche that will sustain their growth. However, both the temporal and molecular details of this process remain poorly understood. Here, we found that metastatic initiating cells (MICs) exhibit a high capacity for lung fibroblast activation as a result of Thrombospondin 2 (THBS2) expression. Importantly, inhibiting the mesenchymal phenotype of MICs by blocking the epithelial-to-mesenchymal transition (EMT)-a ...[more]