Nanowire analysis of cancer-testis antigens as biomarkers of aggressive prostate cancer.

ABSTRACT:

Objective

To demonstrate the ability of the nCounter Analysis System, a nanowire technology, to sensitively and accurately detect cancer-testis antigens (CTAs) in men with prostate cancer and correlate them with disease parameters. The clinical implementation of novel biomarkers is necessary to provide for individual disease treatment planning for men with prostate cancer. The CTAs, as cancer-associated biomarkers that may correlate with aggressive disease, have the potential to play an important role.

Methods

Formalin-fixed, paraffin embedded samples were used from men undergoing radical prostatectomy for prostate cancer. The expression of CTAs along with control genes was measured from formalin-fixed, paraffin-embedded prostate cancer tissues using real-time polymerase cha

SUBMITTER: Takahashi S 

PROVIDER: S-EPMC4695987 | biostudies-literature | 2015 Mar

REPOSITORIES: biostudies-literature