Identification of prosaposin and transgelin as potential biomarkers for gallbladder cancer using quantitative proteomics.

ABSTRACT: Gallbladder cancer is an uncommon but lethal malignancy with particularly high incidence in Chile, India, Japan and China. There is a paucity of unbiased large-scale studies investigating molecular basis of gallbladder cancer. To systematically identify differentially regulated proteins in gallbladder cancer, iTRAQ-based quantitative proteomics of gallbladder cancer was carried out using Fourier transform high resolution mass spectrometry. Of the 2575 proteins identified, proteins upregulated in gallbladder cancer included several lysosomal proteins such as prosaposin, cathepsin Z and cathepsin H. Downregulated proteins included serine protease HTRA1 and transgelin, which have been reported to be downregulated in several other cancers. Novel biomarker candidates including prosaposin and tr

SUBMITTER: Sahasrabuddhe NA 

PROVIDER: S-EPMC4696041 | biostudies-literature | 2014 Apr

REPOSITORIES: biostudies-literature