Association Between Specific Mutations in KRAS Codon 12 and Colorectal Liver Metastasis.

ABSTRACT:

Importance

Currently, one of the most commonly available biomarkers in the treatment of patients with colorectal liver metastases (CRLM) is the Kirsten rat sarcoma viral oncogene homolog (KRAS); however, the prognostic implications of specific mutations of the KRAS gene are still not well defined.

Objective

To investigate the prognostic impact of specific KRAS mutations on patients undergoing liver resection for CRLM.

Design, setting, and participants

This retrospective single-center study was conducted from January 1, 2003, to December 31, 2013. Data about specific KRAS mutations for 331 patients who underwent hepatic resection for CRLM at Johns Hopkins Hospital between 2003 and 2013 were analyzed. Clinicopathological characteristics, perioperative details, and outco

SUBMITTER: Margonis GA 

PROVIDER: S-EPMC4696064 | biostudies-literature | 2015 Aug

REPOSITORIES: biostudies-literature