Mass spectrometry-based analyses showing the effects of secretor and blood group status on salivary N-glycosylation.

ABSTRACT:

Background

The carbohydrate portions of salivary glycoproteins play important roles, including mediating bacterial and leukocyte adhesion. Salivary glycosylation is complex. Many of its glycoproteins present ABO and Lewis blood group determinants. An individual's genetic complement and secretor status govern the expression of blood group antigens. We queried the extent to which salivary glycosylation varies according to blood group and secretor status. First, we screened submandibular/sublingual and parotid salivas collected as ductal secretions for reactivity with a panel of 16 lectins. We selected three lectins that reacted with the largest number of glycoproteins and one that recognized uncommon lactosamine-containing structures. Ductal salivas representing a secretor with compl

SUBMITTER: Albertolle ME 

PROVIDER: S-EPMC4696288 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature