The Michigan Model for Coronary Heart Disease in Type 2 Diabetes: Development and Validation.

ABSTRACT:

Objectives

The aim of this study was to develop and validate a computer simulation model for coronary heart disease (CHD) in type 2 diabetes mellitus (T2DM) that reflects current medical and surgical treatments.

Research design and methods

We modified the structure of the CHD submodel in the Michigan Model for Diabetes to allow for revascularization procedures before and after first myocardial infarction, for repeat myocardial infarctions and repeat revascularization procedures, and for congestive heart failure. Transition probabilities that reflect the direct effects of medical and surgical therapies on outcomes were derived from the literature and calibrated to recently published population-based epidemiologic studies and randomized controlled clinical trials. Monte Carlo

SUBMITTER: Ye W 

PROVIDER: S-EPMC4696433 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature