Ontology highlight
ABSTRACT:
SUBMITTER: Messaoudi S
PROVIDER: S-EPMC4696516 | biostudies-literature | 2015 Nov
REPOSITORIES: biostudies-literature
Nature communications 20151130
Despite its high prevalence and economic burden, the aetiology of human hypertension remains incompletely understood. Here we identify the transcription factor GATA5, as a new regulator of blood pressure (BP). GATA5 is expressed in microvascular endothelial cells and its genetic inactivation in mice (Gata5-null) leads to vascular endothelial dysfunction and hypertension. Endothelial-specific inactivation of Gata5 mimics the hypertensive phenotype of the Gata5-null mice, suggestive of an importan ...[more]