Manganese in teeth and neurodevelopment in young Mexican-American children.

ABSTRACT:

Introduction

Manganese (Mn) is an essential nutrient but higher exposure has been associated with poorer neurodevelopment in children.

Methods

We measured Mn levels in prenatal (Mnpre) (n=197) and postnatal (Mnpost) dentin (n=193) from children's shed teeth using laser ablation inductively coupled plasma mass spectroscopy and examined the relationship with children's scores on the Mental Development Index (MDI) and Psychomotor Development Index (PDI) on the Bayley Scales of Infant Development at 6, 12, and 24-months. We explored non-linear associations and interactions by sex, blood lead concentrations and maternal iron status during pregnancy.

Results

A two-fold increase of Mnpost levels in dentin was associated with small decreases in MDI at 6-months and 12-months o

SUBMITTER: Gunier RB 

PROVIDER: S-EPMC4696558 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature