Podocyte-Specific Deletion of Yes-Associated Protein Causes FSGS and Progressive Renal Failure.

ABSTRACT: FSGS is the most common primary glomerular disease underlying ESRD in the United States and is increasing in incidence globally. FSGS results from podocyte injury, yet the mechanistic details of disease pathogenesis remain unclear. This has resulted in an unmet clinical need for cell-specific therapy in the treatment of FSGS and other proteinuric kidney diseases. We previously identified Yes-associated protein (YAP) as a prosurvival signaling molecule, the in vitro silencing of which increases podocyte susceptibility to apoptotic stimulus. YAP is a potent oncogene that is a prominent target for chemotherapeutic drug development. In this study, we tested the hypothesis that podocyte-specific deletion of Yap leads to proteinuric kidney disease through increased podocyte apoptosis. Yap was se

SUBMITTER: Schwartzman M 

PROVIDER: S-EPMC4696566 | biostudies-literature | 2016 Jan

REPOSITORIES: biostudies-literature