The Role of Shear Stress in Arteriovenous Fistula Maturation and Failure: A Systematic Review.

ABSTRACT:

Introduction

Non-maturation and post-maturation venous stenosis are the primary causes of failure within arteriovenous fistulae (AVFs). Although the exact mechanisms triggering failure remain unclear, abnormal hemodynamic profiles are thought to mediate vascular remodelling and can adversely impact on fistula patency.

Aim

The review aims to clarify the role of shear stress on outward remodelling during maturation and evaluate the evidence supporting theories related to the localisation and development of intimal hyperplasia within AVFs.

Methods

A systematic review of studies comparing remodelling data with hemodynamic data obtained from computational fluid dynamics of AVFs during and after maturation was conducted.

Results

Outward remodelling occurred to reduce

SUBMITTER: Browne LD 

PROVIDER: S-EPMC4696682 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature